" /> E3 Ubiquitin-Protein Ligase MDM2 - CISMeF





Preferred Label : E3 Ubiquitin-Protein Ligase MDM2;

NCIt synonyms : MDM2 Protein; Double Minute 2 Protein; MDM 2 Protein; p53-Binding Protein MDM2; MDM2; p53 Binding Protein; HDM2; Ubiquitin-Protein Ligase E3 MDM2; Oncoprotein Mdm2; EC 2.3.2.27; RING-Type E3 Ubiquitin Transferase Mdm2;

NCIt definition : E3 ubiquitin-protein ligase Mdm2 (491 aa, 55 kDa) is encoded by the human MDM2 gene. This protein is involved in the mediation of the ubiquitination and degradation of protein substrates, and the inhibition of apoptosis induction that is mediated by cellular tumor antigen p53.;

NCIt note : Inhibits p53 trans-activation, cell cycle arrest, and apoptosis. MDM2 binds p53 in the cell cycle at S/G2M phase and targets p53 for proteasome-mediated proteolysis. MDM2 also inhibits Rb protein and binds p14(ARF), ribosomal protein L5, and specifically to RNA. MDM2 gene expression is induced by DNA damage and regulated by the Ras-MAP kinase pathway. Some soft tissue sarcomas carry amplified MDM2 and overexpress MDM2 protein. (from SWISS-PROT Q00987, OMIM 164785, and NCI);

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29/04/2024


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