Matrix Metalloproteinase-9

Preferred Label : Matrix Metalloproteinase-9;

NCIt synonyms : Gelatinase B; MMP9; Macrophage Gelatinase; Type V Collagenase; 92 kDa Type IV Collagenase; 92 kDa Gelatinase; Matrix Metalloprotease-9; MMP-9; Matrix Metalloprotease 9; Matrix Metalloproteinase 9; EC 3.4.24.35; GELB;

NCIt definition : Matrix metalloproteinase-9 (707 aa, 78 kDa) is encoded by the human MMP9 gene. This protein plays a role in collagen degradation, macrophage differentiation and cell migration.;

NCIt note : Protein_Plays_Role_In_Biological_Process :Degrades extracellular matrix types I and V Gelatin and types IV and V Collagen;

Details

Origin ID

C17575;

UMLS CUI

C3657771;

Currated CISMeF NLP mapping
- Gelatinase B (substance) [SNOMED CT concept]
False automatic mappings
- AGAR [SMS substance]
OMIM relation
- Matrix metalloproteinase 9 [OMIM gene]
See also inter- (CISMeF)
- Matrix metallopeptidase 9 [LOINC component]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Gelatinase B (substance) [SNOMED CT concept]
- MMP-9 [LOINC component]
- MMP9 protein, human [MeSH Supplementary Concept]
- MMP9 protein, human [MeSH concept]
- matrix metalloproteinase 9 [MeSH Descriptor]
- matrix metalloproteinase 9 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MMP9 Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Rebimastat [NCIt concept]
gene_product_has_biochemical_function
- Collagenase [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Inhibition of Matrix Metalloproteinases Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Embryogenesis [NCIt concept]
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Protein Degradation Process [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Andecaliximab [NCIt concept]
- Rebimastat [NCIt concept]

Keyword's position in hierarchy(ies) :

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