72 kDa Type IV Collagenase

Preferred Label : 72 kDa Type IV Collagenase;

NCIt synonyms : Gelatinase A; MMP2; MMP-2; Matrix Metalloproteinase-2; TBE-1; Matrix Metalloproteinase 2; Matrix Metalloprotease 2; EC 3.4.24.24; 72kDa Gelatinase; Matrix Metalloprotease-2; 72 kDa Gelatinase; 72kDa Type IV Collagenase;

NCIt definition : 72 kDa type IV collagenase (660 aa, 74 kDa) is encoded by the human MMP2 gene. This protein is involved in both proteolysis and angiogenesis.;

Details

Origin ID

C17592;

UMLS CUI

C2001898;

Currated CISMeF NLP mapping
- Gelatinase A (substance) [SNOMED CT concept]
False automatic mappings
- Exfoliation syndrome [OMIM Phenotype]
OMIM relation
- Matrix metalloproteinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Gelatinase A (substance) [SNOMED CT concept]
- MMP2 protein, human [MeSH Supplementary Concept]
- MMP2 protein, human [MeSH concept]
- matrix metalloproteinase 2 [MeSH concept]
- matrix metalloproteinase 2 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MMP2 Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Rebimastat [NCIt concept]
gene_product_has_biochemical_function
- Collagenase [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Inhibition of Matrix Metalloproteinases Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Inflammatory Response [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Autologous CLTX-targeted CAR T-lymphocytes CHM 1101 [NCIt concept]
- Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes [NCIt concept]
- Halofuginone [NCIt concept]
- Halofuginone Hydrobromide [NCIt concept]
- Rebimastat [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients