" /> BRAF wt Allele - CISMeF





Preferred Label : BRAF wt Allele;

NCIt synonyms : Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1 Gene; RAFB1; B-raf-1; NS7; BRAF1; v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene; B-Raf Proto-Oncogene, Serine/Threonine Kinase wt Allele; v-Raf Murine Sarcoma Viral Oncogene Homolog B Gene; B-RAF1; B-Raf Proto-Oncogene Serine/Threonine-Protein Kinase (P94) Gene;

NCIt definition : Human BRAF wild-type allele is located within 7q34 and is approximately 190 kb in length. This allele, which encodes B-Raf proto-oncogene serine/threonine-protein kinase protein, plays a role in the transduction of mitogenic signals from the cell membrane to the nucleus. A specific activating somatic mutation in the BRAF gene is associated with several types of cancer such as colorectal and thyroid carcinomas and malignant melanoma.;

NCIt note : Somatic BRAF gene mutations have also been detected in lung adenocarcinoma, non-small cell lung cancer, non-Hodgkin lymphoma and cardiofaciocutaneous syndrome. Fusion of the TRIM24 gene with the BRAF gene via translocation results in the production of a TIF1-alpha-B-Raf oncoprotein.;

GenBank Accession Number : NM_004333;

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29/04/2024


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