Interleukin-8 - CISMeF

Preferred Label : Interleukin-8;

NCIt synonyms : Anionic Neutrophil Activating Peptide; Macrophage-Derived Chemotactic Factor; Neutrophil Chemotactic Factor; Monocyte-Derived Neutrophil-Activating Peptide; Monocyte-Derived Neutrophil Chemotactic Factor; Granulocyte Chemotactic Peptide Interleukin 8; IL-8; Interleukin 8; Neutrophil Activation Peptide; GCP-IL-8; NAP-1; MDNCF; Leukocyte Adhesion Inhibitor; Anionic Neutrophil-Activating Peptide; IL8; Neutrophil Activation Factor; Neutrophil-Activating Peptide 1; GCP-1; Granulocyte Chemotactic Protein 1; CXCL8; T-Cell Chemotactic Factor; Beta Endothelial Cell-Derived Neutrophil Activating Peptide; Lymphocyte Derived Neutrophil Activating Peptide; Protein 3-10C; C-X-C Motif Chemokine 8; Neutrophil-Activating Protein 1; MONAP; Beta-Thromboglobulin-Like Protein; Alveolar Macrophage Chemotactic Factor I; Lung Giant Cell Carcinoma-Derived Chemotactic Protein;

NCIt definition : Interleukin-8 (99 aa, 11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation.;

NCIt note : Interleukin-8 is cleaved into the following seven chains: MDNCF-a (GCP/IL-8 protein IV, IL8/NAP1 form I), Interleukin-8 ((Ala-IL-8)77, GCP/IL-8 protein II, IL-8(1-77), IL8/NAP1 form II, MDNCF-b), IL-8(5-77), IL-8(6-77) ((Ser-IL-8)72, GCP/IL-8 protein I, IL8/NAP1 form III, lymphocyte-derived neutrophil-activating factor, LYNAP, MDNCF-c, neutrophil-activating factor, NAF), IL-8(7-77) (GCP/IL-8 protein V, IL8/NAP1 form IV), IL-8(8-77) (GCP/IL-8 protein VI, IL8/NAP1 form V), and IL-8(9-77) (GCP/IL-8 protein III; IL8/NAP1 form VI). (UniProt);

Details

Origin ID

C20473;

UMLS CUI

C1698756;

Currated CISMeF NLP mapping
- Interleukin 8 [LOINC component]
- Interleukin-8 [FMA entity]
- Interleukin-8 [MeSH Descriptor]
- Interleukin-8 [MeSH concept]
- Interleukin-8 (substance) [SNOMED CT concept]
- interleukin-8 [SNOMED Notion]
False automatic mappings
- interleukin 8 (77) [MeSH concept]
- interleukin 8 (77) [MeSH Supplementary Concept]
- interleukin-8 (3-25) [MeSH concept]
- interleukin-8 (3-25) [MeSH Supplementary Concept]
OMIM relation
- Chemokine, cxc motif, ligand 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CXCL8 protein, human [MeSH concept]
- CXCL8 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CXC Cytokine Gene [NCIt concept]
- CXCL8 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
- Interleukin Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine Network Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Free Radical Induced Apoptosis Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- Granulocyte Adhesion Pathway [NCIt concept]
- Hematopoiesis Pathway [NCIt concept]
- IL17 Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Local Acute Inflammatory Response Pathway [NCIt concept]
- Lymphocyte Adhesion Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Wound Repair Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]
is_target
- Adakitug [NCIt concept]
- CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes [NCIt concept]
- TSP-1 Mimetic ABT-510 [NCIt concept]

Keyword's position in hierarchy(ies) :

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