RIG-I-Like Receptor Signaling Pathway

Preferred Label : RIG-I-Like Receptor Signaling Pathway;

Alternative definition : KEGG: Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.;

KEGG ID : hsa04622;

Details

Origin ID

C91507;

UMLS CUI

C2984316;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- ATP-Dependent RNA Helicase DDX3X [NCIt concept]
- ATP-Dependent RNA Helicase DHX58 [NCIt concept]
- Antiviral Innate Immune Response Receptor RIG-I [NCIt concept]
- C-X-C Motif Chemokine 10 [NCIt concept]
- Caspase-10 [NCIt concept]
- Caspase-8 [NCIt concept]
- E3 Ubiquitin/ISG15 Ligase TRIM25 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon [NCIt concept]
- Interferon Alpha-1/13 [NCIt concept]
- Interferon Alpha-2 [NCIt concept]
- Interferon Beta [NCIt concept]
- Interferon Omega-1 [NCIt concept]
- Interferon Regulatory Factor 3 [NCIt concept]
- Interferon Regulatory Factor 7 [NCIt concept]
- Interferon-Induced Helicase C Domain-Containing Protein 1 [NCIt concept]
- Interleukin-12 Subunit Alpha [NCIt concept]
- Interleukin-12 Subunit Beta [NCIt concept]
- Interleukin-8 [NCIt concept]
- Mitochondrial Antiviral-Signaling Protein [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 11 [NCIt concept]
- Mitogen-Activated Protein Kinase 12 [NCIt concept]
- Mitogen-Activated Protein Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Beta [NCIt concept]
- NLR Family Member X1 [NCIt concept]
- OTU Domain-Containing Protein 5 [NCIt concept]
- Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Serine/Threonine-Protein Kinase TBK1 [NCIt concept]
- Stimulator of Interferon Genes Protein [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 3 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- TRAF Family Member-Associated NF-Kappa-B Activator [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase CYLD [NCIt concept]
pathway_has_gene_element
- CASP10 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CXCL10 wt Allele [NCIt concept]
- CXCL8 wt Allele [NCIt concept]
- CYLD wt Allele [NCIt concept]
- DDX3X wt Allele [NCIt concept]
- DHX58 wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- IFIH1 wt Allele [NCIt concept]
- IFNA13 wt Allele [NCIt concept]
- IFNA2 wt Allele [NCIt concept]
- IFNB1 wt Allele [NCIt concept]
- IFNW1 wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IKBKE wt Allele [NCIt concept]
- IL12A wt Allele [NCIt concept]
- IL12B wt Allele [NCIt concept]
- IRF3 wt Allele [NCIt concept]
- IRF7 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK12 wt Allele [NCIt concept]
- MAPK13 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MAVS wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NFKBIB wt Allele [NCIt concept]
- NLRX1 wt Allele [NCIt concept]
- OTUD5 wt Allele [NCIt concept]
- PIN1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RIGI wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- STING1 wt Allele [NCIt concept]
- TANK wt Allele [NCIt concept]
- TBK1 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]
- TRAF3 wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]
- TRIM25 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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