Interferon Alpha-2

Preferred Label : Interferon Alpha-2;

NCIt synonyms : Interferon Alpha-A; IFNA2; IFNA2 Protein; LeIF A; Alpha-2a Interferon; Interferon Alpha 2b; IFN-Alpha-2; Interferon Alpha 2a; Interferon Alpha A; Interferon Alpha 2; IFN-AlphaA; Alpha-2-Interferon;

NCIt definition : Interferon alpha-2 (188 aa, 22 kDa) is encoded by the human IFNA2 gene. This protein is involved in antiviral defense, cell-cell signaling, and immune activation.;

NCIt note : There are 3 forms of interferon alpha-2. Alpha-2a is the canonical form. Alpha-2b is the result of a SNP that has the variant amino acid Lys46Arg. Alpha-2c has the amino acid variation Lys46Arg, and an additional variation His57Arg. (UniProt);

Details

Origin ID

C26318;

UMLS CUI

C0535872;

Currated CISMeF NLP mapping
- interferon alpha-2 [MeSH concept]
False automatic mappings
- interferon, alfa 2(125-129) [MeSH concept]
- interferon, alfa 2(125-129) [MeSH Supplementary Concept]
- interferon, alpha 2(1-110) [MeSH concept]
- interferon, alpha 2(1-110) [MeSH Supplementary Concept]
- interferon, alpha 2(111-153) [MeSH concept]
- interferon, alpha 2(111-153) [MeSH Supplementary Concept]
OMIM relation
- Interferon, alpha-2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- IFNA2 protein, human [MeSH concept]
- IFNA2 protein, human [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- Interferon alfa-2a (substance) [SNOMED CT concept]
- Interferon alfa-2b (substance) [SNOMED CT concept]
Validated automatic mappings to NTBT
- Interferon alfa (substance) [SNOMED CT concept]
- Interferon alpha [LOINC component]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- IFNA2 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Macrophage [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Interferon Type I [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Autophagy Regulation Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Cytosolic DNA-Sensing Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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