Jak-STAT Signaling Pathway

Preferred Label : Jak-STAT Signaling Pathway;

NCIt related terms : JAK/STAT; Janus Kinase/Signal Transducer and Activator of Transcription;

Alternative definition : KEGG: The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.;

KEGG ID : hsa04630;

Details

Origin ID

C91519;

UMLS CUI

C2984327;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- CREB-Binding Protein [NCIt concept]
- Cardiotrophin-Like Cytokine Factor 1 [NCIt concept]
- Cytokine Receptor Common Subunit Beta [NCIt concept]
- Cytokine Receptor Common Subunit Gamma [NCIt concept]
- Cytokine Receptor-Like Factor 2 [NCIt concept]
- Cytokine-Inducible SH2-Containing Protein [NCIt concept]
- E3 SUMO-Protein Ligase PIAS1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- Erythropoietin [NCIt concept]
- G1/S-Specific Cyclin-D3 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Granulocyte Colony-Stimulating Factor [NCIt concept]
- Granulocyte Colony-Stimulating Factor Receptor [NCIt concept]
- Granulocyte-Macrophage Colony-Stimulating Factor [NCIt concept]
- Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Growth Hormone Receptor [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Interferon Alpha-1/13 [NCIt concept]
- Interferon Alpha-2 [NCIt concept]
- Interferon Alpha/Beta Receptor 1 [NCIt concept]
- Interferon Alpha/Beta Receptor 2 [NCIt concept]
- Interferon Beta [NCIt concept]
- Interferon Gamma [NCIt concept]
- Interferon Gamma Receptor 1 [NCIt concept]
- Interferon Gamma Receptor 2 [NCIt concept]
- Interferon Lambda-1 [NCIt concept]
- Interferon Lambda-2 [NCIt concept]
- Interferon Lambda-3 [NCIt concept]
- Interferon Omega-1 [NCIt concept]
- Interleukin-10 Receptor Subunit Alpha [NCIt concept]
- Interleukin-10 Receptor Subunit Beta [NCIt concept]
- Interleukin-11 [NCIt concept]
- Interleukin-11 Receptor Subunit Alpha [NCIt concept]
- Interleukin-12 Receptor Subunit Beta-1 [NCIt concept]
- Interleukin-12 Receptor Subunit Beta-2 [NCIt concept]
- Interleukin-12 Subunit Alpha [NCIt concept]
- Interleukin-12 Subunit Beta [NCIt concept]
- Interleukin-13 [NCIt concept]
- Interleukin-13 Receptor Subunit Alpha-1 [NCIt concept]
- Interleukin-13 Receptor Subunit Alpha-2 [NCIt concept]
- Interleukin-15 [NCIt concept]
- Interleukin-15 Receptor Subunit Alpha [NCIt concept]
- Interleukin-19 [NCIt concept]
- Interleukin-2 [NCIt concept]
- Interleukin-2 Receptor Subunit Alpha [NCIt concept]
- Interleukin-2 Receptor Subunit Beta [NCIt concept]
- Interleukin-20 [NCIt concept]
- Interleukin-21 [NCIt concept]
- Interleukin-21 Receptor [NCIt concept]
- Interleukin-22 [NCIt concept]
- Interleukin-23 Receptor [NCIt concept]
- Interleukin-23 Subunit Alpha [NCIt concept]
- Interleukin-24 [NCIt concept]
- Interleukin-3 [NCIt concept]
- Interleukin-3 Receptor Subunit Alpha [NCIt concept]
- Interleukin-4 [NCIt concept]
- Interleukin-4 Receptor Subunit Alpha [NCIt concept]
- Interleukin-5 [NCIt concept]
- Interleukin-5 Receptor Subunit Alpha [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-6 Receptor Subunit Alpha [NCIt concept]
- Interleukin-6 Receptor Subunit Beta [NCIt concept]
- Interleukin-7 [NCIt concept]
- Interleukin-7 Receptor Subunit Alpha [NCIt concept]
- Interleukin-9 [NCIt concept]
- Interleukin-9 Receptor [NCIt concept]
- Leptin [NCIt concept]
- Leptin Receptor [NCIt concept]
- Leukemia Inhibitory Factor [NCIt concept]
- Leukemia Inhibitory Factor Receptor [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Non-Receptor Tyrosine-Protein Kinase TYK2 [NCIt concept]
- Oncostatin-M [NCIt concept]
- Oncostatin-M-Specific Receptor Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Prolactin [NCIt concept]
- Prolactin Receptor [NCIt concept]
- Protein Sprouty Homolog 2 [NCIt concept]
- Protein Sprouty Homolog 4 [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Serine/Threonine-Protein Kinase Pim-1 [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- Signal Transducer and Activator of Transcription 2 [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Signal Transducer and Activator of Transcription 4 [NCIt concept]
- Signal Transducer and Activator of Transcription 5A [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Signal Transducer and Activator of Transcription 6 [NCIt concept]
- Soluble Interleukin-6 Receptor Subunit Alpha [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Sprouty-Related, EVH1 Domain-Containing Protein 1 [NCIt concept]
- Suppressor of Cytokine Signaling 1 [NCIt concept]
- Suppressor of Cytokine Signaling 2 [NCIt concept]
- Suppressor of Cytokine Signaling 3 [NCIt concept]
- Thrombopoietin Receptor [NCIt concept]
- Thymic Stromal Lymphopoietin [NCIt concept]
- Thyroid Peroxidase [NCIt concept]
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 11 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 2 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 6 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CCND3 wt Allele [NCIt concept]
- CISH wt Allele [NCIt concept]
- CLCF1 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- CRLF2 wt Allele [NCIt concept]
- CSF2 wt Allele [NCIt concept]
- CSF2RA wt Allele [NCIt concept]
- CSF2RB wt Allele [NCIt concept]
- CSF3 wt Allele [NCIt concept]
- CSF3R wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- EPO wt Allele [NCIt concept]
- GHR wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IFNA1 wt Allele [NCIt concept]
- IFNA13 wt Allele [NCIt concept]
- IFNA2 wt Allele [NCIt concept]
- IFNAR1 wt Allele [NCIt concept]
- IFNAR2 wt Allele [NCIt concept]
- IFNB1 wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- IFNGR1 wt Allele [NCIt concept]
- IFNGR2 wt Allele [NCIt concept]
- IFNL1 wt Allele [NCIt concept]
- IFNL2 wt Allele [NCIt concept]
- IFNL3 wt Allele [NCIt concept]
- IFNW1 wt Allele [NCIt concept]
- IL10RA wt Allele [NCIt concept]
- IL10RB wt Allele [NCIt concept]
- IL11 wt Allele [NCIt concept]
- IL11RA wt Allele [NCIt concept]
- IL12A wt Allele [NCIt concept]
- IL12B wt Allele [NCIt concept]
- IL12RB1 wt Allele [NCIt concept]
- IL12RB2 wt Allele [NCIt concept]
- IL13 wt Allele [NCIt concept]
- IL13RA1 wt Allele [NCIt concept]
- IL13RA2 wt Allele [NCIt concept]
- IL15 wt Allele [NCIt concept]
- IL15RA wt Allele [NCIt concept]
- IL19 wt Allele [NCIt concept]
- IL2 wt Allele [NCIt concept]
- IL20 wt Allele [NCIt concept]
- IL21 wt Allele [NCIt concept]
- IL21R wt Allele [NCIt concept]
- IL22 wt Allele [NCIt concept]
- IL23A wt Allele [NCIt concept]
- IL23R wt Allele [NCIt concept]
- IL24 wt Allele [NCIt concept]
- IL2RA wt Allele [NCIt concept]
- IL2RB wt Allele [NCIt concept]
- IL2RG wt Allele [NCIt concept]
- IL3 wt Allele [NCIt concept]
- IL3RA wt Allele [NCIt concept]
- IL4 wt Allele [NCIt concept]
- IL4R wt Allele [NCIt concept]
- IL5 wt Allele [NCIt concept]
- IL5RA wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- IL6R wt Allele [NCIt concept]
- IL6ST wt Allele [NCIt concept]
- IL7 wt Allele [NCIt concept]
- IL7R wt Allele [NCIt concept]
- IL9 wt Allele [NCIt concept]
- IL9R wt Allele [NCIt concept]
- JAK1 wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- LEP wt Allele [NCIt concept]
- LEPR wt Allele [NCIt concept]
- LIF wt Allele [NCIt concept]
- LIFR wt Allele [NCIt concept]
- MPL wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- OSM wt Allele [NCIt concept]
- OSMR wt Allele [NCIt concept]
- PIAS1 wt Allele [NCIt concept]
- PIAS3 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PIM1 wt Allele [NCIt concept]
- PRL wt Allele [NCIt concept]
- PRLR wt Allele [NCIt concept]
- PTPN11 wt Allele [NCIt concept]
- PTPN2 wt Allele [NCIt concept]
- PTPN6 wt Allele [NCIt concept]
- SOCS1 wt Allele [NCIt concept]
- SOCS2 wt Allele [NCIt concept]
- SOCS3 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- SPRED1 wt Allele [NCIt concept]
- SPRY2 wt Allele [NCIt concept]
- SPRY4 wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]
- STAT2 wt Allele [NCIt concept]
- STAT3 wt Allele [NCIt concept]
- STAT4 wt Allele [NCIt concept]
- STAT5A wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]
- STAT6 wt Allele [NCIt concept]
- TPO wt Allele [NCIt concept]
- TSLP wt Allele [NCIt concept]
- TYK2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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