Interleukin-23 Receptor

Preferred Label : Interleukin-23 Receptor;

NCIt synonyms : IL23R; IL-23 Receptor; IL23 Receptor; IL-23R; Interleukin 23 Receptor;

NCIt definition : Interleukin-23 receptor (629 aa, 72 kDa) is encoded by the human IL23R gene. This protein plays a role in JAK-STAT signaling and immune cell activation.;

NCIt note : Interleukin-23 receptor binds to interleukin-23 subunit alpha (IL23A) but signaling is dependent on binding of a IL23A/IL12B dimer binding to an IL23/IL12RB1 dimeric receptor complex.;

Details

Origin ID

C147900;

UMLS CUI

C1872104;

Automatic exact mappings (from CISMeF team)
- Interleukin 23 receptor [OMIM gene]
- interleukin 23 receptor [ORDO Gene]
- interleukin 23 receptor [HGNC gene]
- interleukin-23 receptor activity [GO term]
OMIM relation
- Interleukin 23 receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL23R protein, human [MeSH Supplementary Concept]
- IL23R protein, human [MeSH concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL23R Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Interleukin-23 Receptor Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Antimicrobial Effect [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- NK Cell Activation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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