Interleukin-13 Receptor Subunit Alpha-1

Preferred Label : Interleukin-13 Receptor Subunit Alpha-1;

NCIt synonyms : CD213a1 Antigen; IL13RA1; Interleukin-13 Receptor Alpha; IL13 Receptor Alpha 1; IL13 Receptor Alpha-1 Chain; CT19; IL-13R-Alpha-1; IL-13RA1; IL-13R Subunit Alpha-1; Cancer/Testis Antigen 19; Interleukin-13 Receptor, Alpha; IL-13 Receptor Subunit Alpha-1; Interleukin-13 Receptor Alpha 1;

NCIt definition : Interleukin-13 receptor subunit alpha-1 (427 aa, 49 kDa) is encoded by the human IL13RA1 gene. This protein is involved in cytokine-mediated signal transduction.;

NCIt note : This protein is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.;

Details

Origin ID

C41230;

UMLS CUI

C1528378;

OMIM relation
- Interleukin 13 receptor, alpha-1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL13RA1 protein, human [MeSH concept]
- IL13RA1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL13RA1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Cintredekin Besudotox [NCIt concept]

Keyword's position in hierarchy(ies) :

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