Tyrosine-Protein Kinase JAK3

Preferred Label : Tyrosine-Protein Kinase JAK3;

NCIt synonyms : JAK3; Janus Kinase 3; EC 2.7.10.2; Janus Kinase-3; JAK-3; Leukocyte Janus Kinase; L-JAK;

NCIt definition : Tyrosine-protein kinase JAK3 (1124 aa, 125 kDa) is encoded by the human JAK3 gene. This protein is involved in T-cell development, immunity, signaling and tyrosine phosphorylation.;

NCIt note : Janus kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.;

Details

Origin ID

C28492;

UMLS CUI

C0253456;

Currated CISMeF NLP mapping
- janus kinase 3 [MeSH Descriptor]
- janus kinase 3 [MeSH concept]
OMIM relation
- Janus kinase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- JAK3 protein, human [MeSH Supplementary Concept]
- JAK3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Pediatric Oncology Target Genes/Proteins Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- JAK3 Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Natural Killer Cell [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Janus Kinase Family [NCIt concept]
gene_product_has_gene_product_variant
- JAK3 NP_000206.2:p.L857P [NCIt concept]
- JAK3 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL22 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL4 Signaling Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- IL7 Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
- Stat3 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- T-Cell Activation [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Cerdulatinib [NCIt concept]
- Lorpucitinib [NCIt concept]
- Nezulcitinib [NCIt concept]
- Ritlecitinib [NCIt concept]
- Tofacitinib Topical Cream [NCIt concept]

Keyword's position in hierarchy(ies) :

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