NCIt definition : Tyrosine-protein kinase JAK3 (1124 aa, 125 kDa) is encoded by the human JAK3 gene.
This protein is involved in T-cell development, immunity, signaling and tyrosine phosphorylation.;
NCIt note : Janus kinases couple cytokine ligand binding to tyrosine phosphorylation of various
known signaling proteins and of a unique family of transcription factors termed the
signal transducers and activators of transcription, or STATs.;