" /> Soluble Interleukin-6 Receptor Subunit Alpha - CISMeF





Preferred Label : Soluble Interleukin-6 Receptor Subunit Alpha;

NCIt synonyms : Soluble Interleukin-6 Receptor; sIL-6RA; sIL-6R; Soluble IL6RA; Soluble CD126 Antigen; Soluble IL-6R Subunit Alpha; Soluble Interleukin 6 Receptor Subunit Alpha; Soluble IL-6 Receptor; Soluble CD126; Soluble gp80; Soluble IL-6R-Alpha; Soluble IL-6R; Soluble Interleukin 6 Receptor; Soluble IL-6 Receptor Alpha; Soluble IL-6RA; Soluble IL6R;

NCIt definition : Soluble interleukin-6 receptor subunit alpha is encoded by the human IL6R gene. This protein, which is produced by metalloproteinase-mediated cleavage of the membrane-bound form, is involved in the modulation of interleukin-6-mediated signaling by CD4-positive T-lymphocytes.;

NCIt note : Interleukin-6 (IL6) can bind membrane-bound and soluble forms of the interleukin-6 receptor subunit alpha (IL6R) with similar affinities. IL6-soluble IL6R complexes can interact with either membrane-bound or soluble forms of interleukin-6 receptor subunit beta (IL6ST; gp130). Binding of IL6-sIL6R to membrane-bound gp130 promotes IL6-mediated signaling pathways (IL-6 trans-signaling), while binding to soluble gp130 inhibits IL-6 trans-signaling.;

NCI Metathesaurus CUI : CL562744;

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15/05/2024


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