Sarilumab - CISMeF

Preferred Label : Sarilumab;

NCIt synonyms : Immunoglobulin G1, Anti-Human Interleukin 6 Receptor alpha) (Human REGN88 Heavy Chain), Disulfide with Human REGN88 Light Chain, Dimer;

NCIt related terms : IL-6 receptor monoclonal antibodies: sarilumab;

NCIt definition : A recombinant, human immunoglobulin (IgG) monoclonal antibody targeting the interleukin 6 receptor (IL-6R), with potential anti-inflammatory activity. Upon intravenous administration of sarilumab, this agent targets and binds to both soluble IL-6 receptor (sIL-6R) and membrane-bound IL-6 receptor (mIL-6R). This inhibits the binding of the pro-inﬂammatory cytokine IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This may inhibit IL-6/IL-6R-mediated inflammation.;

UNII : NU90V55F8I;

CAS number : 1189541-98-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1189541-98-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Kevzara;

Molecule name : REGN88; SAR153191;

Details

Origin ID

C152302;

UMLS CUI

C3885145;

Automatic exact mappings (from CISMeF team)
- Sarilumab [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Sarilumab (substance) [SNOMED CT concept]
- sarilumab [MeSH Supplementary Concept]
- sarilumab [MeSH concept]
- sarilumab [COVID-19 Thesaurus concept]
See also inter- (CISMeF)
- Kevzara [MeSH concept]
- Product containing sarilumab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sarilumab (medicinal product) [SNOMED CT concept]
- Sarilumab (substance) [SNOMED CT concept]
- sarilumab [ATC Code]
- sarilumab [MeSH concept]
- sarilumab [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- sarilumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- ACC/AHA COVID-19 Appendix Variables [NCIt concept]
- ACC/AHA Cardiovascular and Noncardiovascular Complications of COVID-19 Terminology [NCIt concept]
- Appendix 8: Pharmacological Therapy Terminology [NCIt concept]
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
- Therapies for COVID-19 Terminology [NCIt concept]
has_target
- Interleukin-6 Receptor Subunit Alpha [NCIt concept]
- Soluble Interleukin-6 Receptor Subunit Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

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