NCIt synonyms : Immunoglobulin G1, Anti-Human Interleukin 6 Receptor alpha) (Human REGN88 Heavy Chain),
Disulfide with Human REGN88 Light Chain, Dimer;
NCIt related terms : IL-6 receptor monoclonal antibodies: sarilumab;
NCIt definition : A recombinant, human immunoglobulin (IgG) monoclonal antibody targeting the interleukin
6 receptor (IL-6R), with potential anti-inflammatory activity. Upon intravenous administration
of sarilumab, this agent targets and binds to both soluble IL-6 receptor (sIL-6R)
and membrane-bound IL-6 receptor (mIL-6R). This inhibits the binding of the pro-inflammatory
cytokine IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated
signal transduction pathway. This may inhibit IL-6/IL-6R-mediated inflammation.;