Interleukin-6 Receptor Subunit Alpha

Preferred Label : Interleukin-6 Receptor Subunit Alpha;

NCIt synonyms : Interleukin-6 Receptor Alpha Subunit; IL-6R 1; gp80; Interleukin-6 Receptor Alpha Chain; Membrane Glycoprotein 80; Interleukin-6-Receptor Alpha Subunit; IL-6R-Alpha; IL-6RA; CD126 Antigen; IL-6 Receptor Subunit Alpha; IL-6R Subunit Alpha; Interleukin 6 Receptor; IL6R; IL-6R; Interleukin-6 Receptor; IL6RA;

NCIt definition : Interleukin-6 receptor subunit alpha (468 aa, 52 kDa) is encoded by the human IL6R gene. This protein plays a role in regulation of the immune response, interleukin-6-mediated signaling, and hematopoiesis.;

NCIt note : Interleukin 6 receptor subunit alpha contains an IgC2 domain, 2 FNIII cytokine-binding domains, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. A soluble IL6R may be released from the membrane by proteolysis. The IL6R subunit of the IL6 receptor complex binds to the potent pleiotropic cytokine IL6 with low affinity, but does not transduce a signal. Signal activation requires association with IL6ST.;

Details

Origin ID

C38921;

UMLS CUI

C1699800;

Currated CISMeF NLP mapping
- Interleukin-6 receptor alpha subunit [MeSH concept]
- interleukin-6 receptor alpha subunit [MeSH Descriptor]
OMIM relation
- Interleukin 6 receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL6R protein, human [MeSH concept]
- IL6R protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL6R Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Recombinant Interleukin-6 [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Recombinant Interleukin-6 [NCIt concept]
- Sarilumab [NCIt concept]
- Tocilizumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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