" /> Tocilizumab - CISMeF





Preferred Label : Tocilizumab;

NCIt synonyms : Immunoglobulin G1, Anti-(Human Interleukin 6 Receptor) (Human-Mouse Monoclonal MRA Heavy Chain), Disulfide with Human-Mouse Monoclonal MRA Kappa-Chain, Dimer; MRA;

NCIt related terms : IL-6 receptor monoclonal antibodies: tocilizumab;

NCIt definition : A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. IL-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders, certain types of cancers and possibly various other inflammatory conditions.;

UNII : I031V2H011;

CAS number : 375823-41-9;

Drug name : RoActemra; Actemra;

Molecule name : R-1569;

ChEBI ID : CHEBI:64360;

Codes from synonyms : 501;

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30/07/2025


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