Preferred Label : Recombinant Interleukin-6;
NCIt synonyms : Myeloid Differentiation Inducing Protein; HSF; B Cell Differentiation Factor 2; HPGF; B-Cell Stimulatory Factor-2; IFN Beta 2; Hepatocyte Stimulating Factor; Plasmacytoma Growth Factor; IL-6; Hybridoma Growth Factor; Therapeutic Interleukin-6;
NCIt related terms : Interleukin-6; HUMAN INTERLEUKIN-6;
NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to the
endogenous cytokine interleukin-6 (IL-6) with antiapoptotic, proinflammatory, antiinflammatory,
proproliferative and proangiogenic activities. IL-6 binds to its receptor (IL-6R),
activating a receptor-CD130 receptor complex; the CD130 portion of the complex is
a signal transduction protein that activates JAK kinases and Ras-mediated signaling
pathways, which in turn activate downstream signaling pathways, resulting in the activation
of various transcription factors (STAT, ELK-1, NF-IL-6, etc.) and gene transcription.
The physiological effects of IL-6 are complex and varied and include hematopoietic,
pyrogenic and thermogenic, proinflammatory, antiinflammatory, proproliferative (anti-apoptotic),
and angiogenic effects.;
Alternative definition : NCI-GLOSS: One of a group of related proteins made by leukocytes (white blood cells)
and other cells in the body. Interleukin-6 is made mainly by some T lymphocytes. It
causes B lymphocytes to make more antibodies and also causes fever by affecting areas
of the brain that control body temperature. Interleukin-6 made in the laboratory is
used as a biological response modifier to boost the immune system in cancer therapy.
Interleukin-6 is a type of cytokine.;
UNII : 4O4QWG0B3C;
Drug name : Sigosix;
Codes from synonyms : CDR0000044421; CDR0000044045;
Origin ID : C591;
UMLS CUI : C1527132;
Semantic type(s)
- Validated automatic mappings to NTBT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
