Hematopoietic Cell Lineage Pathway

Preferred Label : Hematopoietic Cell Lineage Pathway;

NCIt related terms : Hematopoietic cell lineage;

Alternative definition : KEGG: Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing this differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.;

KEGG ID : hsa04640;

Details

Origin ID

C91459;

UMLS CUI

C2984271;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 [NCIt concept]
- Aminopeptidase N [NCIt concept]
- Antigen-Presenting Glycoprotein CD1d [NCIt concept]
- B-Cell Receptor CD22 [NCIt concept]
- B-Lymphocyte Antigen CD19 [NCIt concept]
- CD44 Antigen [NCIt concept]
- CD59 Glycoprotein [NCIt concept]
- CD9 Antigen [NCIt concept]
- Complement Decay-Accelerating Factor [NCIt concept]
- Complement Receptor Type 2 [NCIt concept]
- Erythropoietin [NCIt concept]
- Erythropoietin Receptor [NCIt concept]
- Fms-Related Tyrosine Kinase 3 Ligand [NCIt concept]
- Glycophorin-A [NCIt concept]
- Granulocyte Colony-Stimulating Factor [NCIt concept]
- Granulocyte Colony-Stimulating Factor Receptor [NCIt concept]
- Granulocyte-Macrophage Colony-Stimulating Factor [NCIt concept]
- Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- High Affinity Immunoglobulin Gamma Fc Receptor I [NCIt concept]
- Integrin Alpha-1 [NCIt concept]
- Integrin Alpha-2 [NCIt concept]
- Integrin Alpha-3 [NCIt concept]
- Integrin Alpha-4 [NCIt concept]
- Integrin Alpha-5 [NCIt concept]
- Integrin Alpha-6 [NCIt concept]
- Integrin Alpha-IIb [NCIt concept]
- Integrin Alpha-M [NCIt concept]
- Integrin Beta-3 [NCIt concept]
- Interleukin-1 Alpha [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-1 Receptor Type 1 [NCIt concept]
- Interleukin-1 Receptor Type 2 [NCIt concept]
- Interleukin-11 [NCIt concept]
- Interleukin-11 Receptor Subunit Alpha [NCIt concept]
- Interleukin-2 Receptor Subunit Alpha [NCIt concept]
- Interleukin-3 [NCIt concept]
- Interleukin-3 Receptor Subunit Alpha [NCIt concept]
- Interleukin-4 [NCIt concept]
- Interleukin-4 Receptor Subunit Alpha [NCIt concept]
- Interleukin-5 [NCIt concept]
- Interleukin-5 Receptor Subunit Alpha [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-6 Receptor Subunit Alpha [NCIt concept]
- Interleukin-7 [NCIt concept]
- Interleukin-7 Receptor Subunit Alpha [NCIt concept]
- Interleukin-9 Receptor [NCIt concept]
- Kit Ligand [NCIt concept]
- Leukocyte Antigen CD37 [NCIt concept]
- Low Affinity Immunoglobulin Epsilon Fc Receptor [NCIt concept]
- Macrophage Colony-Stimulating Factor 1 [NCIt concept]
- Macrophage Colony-Stimulating Factor 1 Receptor [NCIt concept]
- Monocyte Differentiation Antigen CD14 [NCIt concept]
- Myeloid Cell Surface Antigen CD33 [NCIt concept]
- Neprilysin [NCIt concept]
- Platelet Glycoprotein 4 [NCIt concept]
- Platelet Glycoprotein IX [NCIt concept]
- Platelet Glycoprotein V [NCIt concept]
- Platelet Membrane Glycoprotein 1b Alpha Chain [NCIt concept]
- Platelet Membrane Glycoprotein 1b Beta Chain [NCIt concept]
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
- Soluble Interleukin-6 Receptor Subunit Alpha [NCIt concept]
- T-Cell Surface Antigen CD2 [NCIt concept]
- T-Cell Surface Glycoprotein CD1a [NCIt concept]
- T-Cell Surface Glycoprotein CD1c [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Delta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Epsilon Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Gamma Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD4 [NCIt concept]
- T-Cell Surface Glycoprotein CD5 [NCIt concept]
- T-Cell Surface Glycoprotein CD8 Alpha Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD8 Beta Chain [NCIt concept]
- Thrombopoietin [NCIt concept]
- Transferrin Receptor Protein 1 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
pathway_has_gene_element
- ANPEP wt Allele [NCIt concept]
- CD14 wt Allele [NCIt concept]
- CD19 wt Allele [NCIt concept]
- CD1A wt Allele [NCIt concept]
- CD1C wt Allele [NCIt concept]
- CD1D wt Allele [NCIt concept]
- CD2 wt Allele [NCIt concept]
- CD22 wt Allele [NCIt concept]
- CD33 wt Allele [NCIt concept]
- CD36 wt Allele [NCIt concept]
- CD37 wt Allele [NCIt concept]
- CD38 wt Allele [NCIt concept]
- CD3D wt Allele [NCIt concept]
- CD3E wt Allele [NCIt concept]
- CD3G wt Allele [NCIt concept]
- CD4 wt Allele [NCIt concept]
- CD44 wt Allele [NCIt concept]
- CD5 wt Allele [NCIt concept]
- CD55 wt Allele [NCIt concept]
- CD59 wt Allele [NCIt concept]
- CD8B wt Allele [NCIt concept]
- CD9 wt Allele [NCIt concept]
- CR2 wt Allele [NCIt concept]
- CSF1 wt Allele [NCIt concept]
- CSF1R wt Allele [NCIt concept]
- CSF2 wt Allele [NCIt concept]
- CSF2RA wt Allele [NCIt concept]
- CSF3 wt Allele [NCIt concept]
- CSF3R wt Allele [NCIt concept]
- EPO wt Allele [NCIt concept]
- EPOR wt Allele [NCIt concept]
- FCER2 wt Allele [NCIt concept]
- FCGR1A wt Allele [NCIt concept]
- FLT3 wt Allele [NCIt concept]
- FLT3LG wt Allele [NCIt concept]
- GP1BA wt Allele [NCIt concept]
- GP1BB wt Allele [NCIt concept]
- GP5 wt Allele [NCIt concept]
- GP9 wt Allele [NCIt concept]
- GYPA wt Allele [NCIt concept]
- HLA-DMA wt Allele [NCIt concept]
- HLA-DMB wt Allele [NCIt concept]
- HLA-DQA1 wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- IL11 wt Allele [NCIt concept]
- IL11RA wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL1R1 wt Allele [NCIt concept]
- IL1R2 wt Allele [NCIt concept]
- IL2RA wt Allele [NCIt concept]
- IL3 wt Allele [NCIt concept]
- IL3RA wt Allele [NCIt concept]
- IL4 wt Allele [NCIt concept]
- IL4R wt Allele [NCIt concept]
- IL5 wt Allele [NCIt concept]
- IL5RA wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- IL6R wt Allele [NCIt concept]
- IL7 wt Allele [NCIt concept]
- IL7R wt Allele [NCIt concept]
- IL9R wt Allele [NCIt concept]
- ITGA1 wt Allele [NCIt concept]
- ITGA2 wt Allele [NCIt concept]
- ITGA2B wt Allele [NCIt concept]
- ITGA3 wt Allele [NCIt concept]
- ITGA4 wt Allele [NCIt concept]
- ITGA5 wt Allele [NCIt concept]
- ITGA6 wt Allele [NCIt concept]
- ITGAM wt Allele [NCIt concept]
- ITGB3 wt Allele [NCIt concept]
- KITLG wt Allele [NCIt concept]
- MME wt Allele [NCIt concept]
- TFRC wt Allele [NCIt concept]
- THPO wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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