Glycophorin-A - CISMeF

Preferred Label : Glycophorin-A;

NCIt synonyms : GYPA; GPA; Sialoglycoprotein Alpha; CD235a Antigen; Glycophorin A Protein; Glycophorin A; Erythroid-Lineage-Specific Membrane Sialoglycoprotein; PAS-2; MN Sialoglycoprotein; CD235A;

NCIt definition : Glycophorin-A (150 aa, 16 kDa) is encoded by the human GYPA gene. This protein is involved in red blood cell MN antigenicity.;

NCIt note : Glycophorins A (GYPA) and B (GYPB) are sialoglycoproteins of the human erythrocyte membrane and bear the antigenic determinants for the M/N and S/s blood groups. GYPA and GYPB share 97% sequence homology with for the first 45 amino acids. In addition to the M or N and S or s antigens, which are common in all populations, about 40 related variant phenotypes have been identified. These variants include Dantu, Sat, He, Mg, all the variants of the Miltenberger complex and several isoforms of Sta, and deletion variants Ena, S-s-U- and Mk. Most variants result from recombinations between GYPA and GYPB. (EntrezGene);

Details

Origin ID

C525;

UMLS CUI

C1309526;

Currated CISMeF NLP mapping
- Glycophorin A (substance) [SNOMED CT concept]
- glycophorin A [MeSH concept]
False automatic mappings
- Blood group, mn [OMIM Phenotype]
- Granulomatosis with Polyangiitis [MeSH Descriptor]
- Granulomatosis with polyangiitis [ORDO Disease]
- Granulomatosis with polyangiitis [OMIM Phenotype]
- granulomatosis with polyangiitis [MedlinePlus Topic]
- surrogate mothers [MeSH Descriptor]
OMIM relation
- Blood group, mn [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- GYPA protein, human [MeSH concept]
- GYPA protein, human [MeSH Supplementary Concept]
- Glycophorin A (substance) [SNOMED CT concept]
- glycophorin A [MeSH concept]
gene_encodes_gene_product
- GYPA Gene [NCIt concept]
- Immunoprotein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Erythrocyte [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Glycophorin [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune System Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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