Malaria Pathway

Preferred Label : Malaria Pathway;

NCIt synonyms : Plasmodium sp. Infection Pathway; Plasmodium Infection Pathway;

NCIt related terms : Malaria;

Alternative definition : KEGG: Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form. Sporozoite invasion of hepatocytes is mediated by parasite surface protein like CSP. Subsequent infection into red blood cells (RBCs) by merozoites causes malaria disease via aberrant cytokine production and sequestration of parasite-infected red blood cells (pRBCs) to host endothelium. Microvasculature sequestration in the brain brings about cerebral malaria that can result in death or persisting neurological impairment. PfEMP1 has been suggested as the key adhesive molecule of pRBCs.;

KEGG ID : hsa05144;

Details

Origin ID

C91807;

UMLS CUI

C2984572;

Automatic exact mappings (from CISMeF team)
- MALARIA [WHO-ART Preferred Term]
- Malaria [PASCAL descriptor]
- Malaria [DeCS]
- Malaria [ORDO Disease]
- Malaria [MedDRA Preferred Term]
- Malaria [Bloc CIM-11]
- Malaria [Vue CIM-11]
- Malaria [HPMULTI term]
- Malaria [ICD-9 code]
- Malaria [PASCAL theme]
- Malaria (disorder) [SNOMED CT concept]
- Paludism [MedDRA LLT]
- Papillomavirus [UNVA Disease]
- malaria [MedlinePlus Topic]
- malaria [DO Concept]
- malaria [ICPC-2 Rubric]
- malaria [MeSH Descriptor]
- malaria [MeSH concept]
- malaria [Blood Transfusion thesaurus concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- C-C Motif Chemokine 2 [NCIt concept]
- CD40 Ligand [NCIt concept]
- CD81 Antigen [NCIt concept]
- Cartilage Oligomeric Matrix Protein [NCIt concept]
- E-Selectin [NCIt concept]
- Glycophorin-A [NCIt concept]
- Glycophorin-B [NCIt concept]
- Hepatocyte Growth Factor [NCIt concept]
- Hepatocyte Growth Factor Receptor [NCIt concept]
- Integrin Alpha-L [NCIt concept]
- Integrin Beta-2 [NCIt concept]
- Intercellular Adhesion Molecule 1 [NCIt concept]
- Interferon Gamma [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-10 [NCIt concept]
- Interleukin-12 Subunit Alpha [NCIt concept]
- Interleukin-12 Subunit Beta [NCIt concept]
- Interleukin-18 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-8 [NCIt concept]
- NKG2-D Type II Integral Membrane Protein [NCIt concept]
- P-Selectin [NCIt concept]
- Platelet Glycoprotein 4 [NCIt concept]
- Prolow-Density Lipoprotein Receptor-Related Protein 1 [NCIt concept]
- Syndecan-1 [NCIt concept]
- Syndecan-2 [NCIt concept]
- Syndecan-4 [NCIt concept]
- Toll-Like Receptor 2 [NCIt concept]
- Toll-Like Receptor 4 [NCIt concept]
- Toll-Like Receptor 9 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
- Vascular Cell Adhesion Protein 1 [NCIt concept]
pathway_has_gene_element
- CCL2 wt Allele [NCIt concept]
- CD36 wt Allele [NCIt concept]
- CD40 wt Allele [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- CD81 wt Allele [NCIt concept]
- COMP wt Allele [NCIt concept]
- CXCL8 wt Allele [NCIt concept]
- GYPA wt Allele [NCIt concept]
- GYPB wt Allele [NCIt concept]
- HGF wt Allele [NCIt concept]
- ICAM1 wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- IL10 wt Allele [NCIt concept]
- IL12A wt Allele [NCIt concept]
- IL12B wt Allele [NCIt concept]
- IL18 wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- ITGAL wt Allele [NCIt concept]
- ITGB2 wt Allele [NCIt concept]
- KLRK1 wt Allele [NCIt concept]
- LRP1 wt Allele [NCIt concept]
- MET wt Allele [NCIt concept]
- SDC1 wt Allele [NCIt concept]
- SDC4 wt Allele [NCIt concept]
- SELE wt Allele [NCIt concept]
- SELP wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TLR2 wt Allele [NCIt concept]
- TLR4 wt Allele [NCIt concept]
- TLR9 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- VCAM1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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