Platelet Glycoprotein 4

Preferred Label : Platelet Glycoprotein 4;

NCIt synonyms : CSVTCG-Specific TSP-1 Receptor; CSVTCG-Specific Receptor; PAS IV; Cysteine-Serine-Valine-Threonine-Cysteine-Glycine Specific TSP-1 Receptor; Leukocyte Differentiation Antigen CD36; CD36 Antigen; Platelet Glycoprotein IV; PAS-4; Platelet Collagen Receptor; GP IIIb; Fatty Acid Translocase; Scavenger Receptor Class B Member 3; GPIIIB; GPIV; Thrombospondin Receptor; PAS-4 Protein; FAT; Cluster Determinant 36; Glycoprotein IIIb; GP IV;

NCIt related terms : CD36;

NCIt definition : Platelet glycoprotein 4 (472 aa, 53 kDa) is encoded by the human CD36 gene. This protein is involved in blood coagulation, fatty acid binding, and cell adhesion.;

NCIt note : CSVTCG-Specific Receptor (GP IV) is the receptor for thrombospondins in platelets and various cell lines. GP IV is also the primary receptor for platelet adhesion to collagen and mediates macrophage scavenging of senescent polymorphonuclear cells undergoing apoptosis. GP IV binds cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG). Since thrombospondins are adhesive proteins widely distributed and involved in a variety of adhesive processes, GP IV may have important functions as a cell adhesion molecule.;

Details

Origin ID

C18400;

UMLS CUI

C3887682;

False automatic mappings
- fats [MeSH Descriptor]
OMIM relation
- Cd36 antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Platelet glycoprotein IV [LOINC component]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CD36 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Insulin Resistance Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- PPAR Signaling Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- TSP-1 Induced Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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