Adipocytokine Signaling Pathway

Preferred Label : Adipocytokine Signaling Pathway;

Définition CISMeF : The adipokines, or adipocytokines are cytokines (cell signaling proteins) secreted by adipose tissue. The first adipokine to be discovered was leptin in 1994.;

Alternative definition : KEGG: Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin.;

KEGG ID : hsa04920;

Details

Origin ID

C91486;

UMLS CUI

C2246617;

Automatic exact mappings (from CISMeF team)
- adiponectin-activated signaling pathway [GO term]
- leptin-mediated signaling pathway [GO term]
- tumor necrosis factor-mediated signaling pathway [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 [NCIt concept]
- 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 [NCIt concept]
- 5'-AMP-Activated Protein Kinase Subunit Gamma-2 [NCIt concept]
- Adiponectin [NCIt concept]
- Adiponectin Receptor Protein 1 [NCIt concept]
- Adiponectin Receptor Protein 2 [NCIt concept]
- Agouti-Related Protein [NCIt concept]
- Carnitine O-Palmitoyltransferase 1, Brain Isoform [NCIt concept]
- Carnitine O-Palmitoyltransferase 1, Liver Isoform [NCIt concept]
- Corticotropin [NCIt concept]
- Glucose-6-Phosphatase 3 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Insulin Receptor Substrate 4 [NCIt concept]
- Leptin [NCIt concept]
- Leptin Receptor [NCIt concept]
- Long-Chain-Fatty-Acid-CoA Ligase 1 [NCIt concept]
- Long-Chain-Fatty-Acid-CoA Ligase 3 [NCIt concept]
- Long-Chain-Fatty-Acid-CoA Ligase 6 [NCIt concept]
- Melanotropin Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Beta [NCIt concept]
- NF-Kappa-B Inhibitor Epsilon [NCIt concept]
- Neuropeptide Y [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Alpha [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha [NCIt concept]
- Platelet Glycoprotein 4 [NCIt concept]
- Pro-Opiomelanocortin [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Beta [NCIt concept]
- Retinoic Acid Receptor RXR-Gamma [NCIt concept]
- Serine/Threonine-Protein Kinase STK11 [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Solute Carrier Family 2, Facilitated Glucose Transporter Member 1 [NCIt concept]
- Suppressor of Cytokine Signaling 3 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1B [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 11 [NCIt concept]
pathway_has_gene_element
- ACSL1 wt Allele [NCIt concept]
- ACSL3 wt Allele [NCIt concept]
- ACSL6 wt Allele [NCIt concept]
- ADIPOQ wt Allele [NCIt concept]
- ADIPOR1 wt Allele [NCIt concept]
- ADIPOR2 wt Allele [NCIt concept]
- AGRP wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- CD36 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CPT1A wt Allele [NCIt concept]
- CPT1C wt Allele [NCIt concept]
- G6PC3 wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IRS4 wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- LEP wt Allele [NCIt concept]
- LEPR wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NFKBIB wt Allele [NCIt concept]
- NFKBIE wt Allele [NCIt concept]
- NPY wt Allele [NCIt concept]
- POMC wt Allele [NCIt concept]
- PPARA wt Allele [NCIt concept]
- PPARGC1A wt Allele [NCIt concept]
- PRKAA1 wt Allele [NCIt concept]
- PRKAA2 wt Allele [NCIt concept]
- PRKAG2 wt Allele [NCIt concept]
- PTPN11 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RXRA wt Allele [NCIt concept]
- RXRB wt Allele [NCIt concept]
- RXRG wt Allele [NCIt concept]
- SLC2A1 wt Allele [NCIt concept]
- SOCS3 wt Allele [NCIt concept]
- STAT3 wt Allele [NCIt concept]
- STK11 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TNFRSF1B wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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