NCIt definition : Human AKT2 wild-type allele is located within 19q13.1-q13.2 and is approximately 53
kb in length. This allele, which encodes RAC-beta serine/threonine-protein kinase
protein, is involved in mediation of cell survival and plays a putative role in the
metabolic actions of insulin. AKT2 gene amplification is associated with certain cancers
such as ovarian and pancreatic carcinomas. An allelic variant of AKT2 is associated
with the development of diabetes mellitus type II.;