MAPK8 wt Allele

Preferred Label : MAPK8 wt Allele;

NCIt synonyms : Mitogen-Activated Protein Kinase 8 wt Allele; MAP Kinase 8 Gene; JNK; JNK1A2; JNK1; PRKM8; SAPK1; JNK21B1/2;

NCIt definition : Human MAPK8 wild-type allele is located in the vicinity of 10q11.22 and is approximately 133 kb in length. This allele, which encodes mitogen-activated protein kinase 8 protein, plays a role in the induction of programmed cell death mediated by both tumor necrosis factor-alpha and ultraviolet radiation.;

NCIt note : The MAPK8 gene is expressed as four distinct isoforms as a result of alternative splicing.;

GenBank Accession Number : NM_002750;

Détails

Origin ID

C52878;

UMLS CUI

C1705632;

Automatic exact mappings (from CISMeF team)
- JUN kinase activity [GO term]
- Mitogen-activated protein kinase 8 [OMIM gene]
OMIM relation
- Mitogen-activated protein kinase 8 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 10q21.1 [NCIt concept]
gene_is_element_in_pathway
- 4-1BB-Dependent Immune Response Pathway [NCIt concept]
- ATM Signaling Pathway [NCIt concept]
- Adipocytokine Signaling Pathway [NCIt concept]
- Agrin Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- B-Cell Immune Response Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Bone Remodeling Pathway [NCIt concept]
- CCR5 Signaling Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAP Kinase Regulation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Nerve Growth Factor Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Oxidative Stress Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- SRF Activation Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
- T-Cell Proliferation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

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