TNF Receptor-Associated Factor 2

Preferred Label : TNF Receptor-Associated Factor 2;

NCIt synonyms : TRAF2; Tumor Necrosis Factor Type 2 Receptor Associated Protein 2; Tumor Necrosis Factor Type 2 Receptor Associated Protein 3; E3 Ubiquitin-Protein Ligase TRAF2; EC 6.3.2.-, Formerly; TNF Receptor-Associated Factor-2; Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3; Tumor Necrosis Factor Type 2 Receptor-Associated Protein 2; EC 2.3.2.27;

NCIt definition : TNF receptor-associated factor 2 (501 aa, 56 kDa) is encoded by the human TRAF2 gene. This protein is involved in antibody isotype switching, protein ubiquitination, tumor necrosis factor receptor-dependent signaling, and the regulation of apoptosis.;

NCIt note : TNF receptor-associated factor 2 has high E3 ubiquitin ligase activity when cytoplasmic sphingosine-1-phosphate is present. (UniProt); TNF receptor-associated factor 2 contains a MATH domain, a RING-type zinc finger, 2 TRAF-type zinc fingers, and a coiled coil domain that mediates homo- and hetero-oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains.;

Details

Origin ID

C17812;

UMLS CUI

C4316866;

Currated CISMeF NLP mapping
- TNF Receptor-Associated factor 2 [MeSH Descriptor]
- TNF Receptor-Associated factor 2 [MeSH concept]
OMIM relation
- Tnf receptor-associated factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- TRAF2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Inhibitor [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- TRAF Domain [NCIt concept]
gene_product_is_element_in_pathway
- 4-1BB-Dependent Immune Response Pathway [NCIt concept]
- Adipocytokine Signaling Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- B-Cell Immune Response Pathway [NCIt concept]
- CD40/CD40L Signaling Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- SODD/TNFR1 Signaling Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- TNF Receptor Family Signaling Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- TNFR2 Signaling Pathway [NCIt concept]
- TRAIL Signaling Pathway [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
- p38 MAPK Signaling Pathway PID [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Signal Transduction [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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