TNFR1 Signaling Pathway

Preferred Label : TNFR1 Signaling Pathway;

Alternative definition : BIOCARTA: TNFR1 (p55, CD120a) is the receptor for TNF-alpha and also will bind TNF-beta. Upon binding TNF-alpha a TNFR1 cell is triggered to undergo apoptosis. This critical regulatory process is accomplished by activating the proteolytic caspase cascade that results in the degradation of many critical cellular proteins. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_tnfr1Pathway;

Details

Origin ID

C39254;

UMLS CUI

C1515165;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- BAG Family Molecular Chaperone Regulator 4 [NCIt concept]
- Caspase-2 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-8 [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- DNA-Dependent Protein Kinase Catalytic Subunit [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Lamin-A/C [NCIt concept]
- Lamin-B1 [NCIt concept]
- MAP Kinase-Activating Death Domain Protein [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Nik-Related Protein Kinase [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
pathway_has_gene_element
- BAG4 wt Allele [NCIt concept]
- CASP2 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- DFFB wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- LMNA wt Allele [NCIt concept]
- LMNB1 wt Allele [NCIt concept]
- MADD wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- NRK wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PRKDC wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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