Caspase-8 - CISMeF

Preferred Label : Caspase-8;

NCIt synonyms : MCH5; Caspase-8/Flice; MACH; FADD-Like ICE; CASP8 Protein; FLICE; FADD-homologous ICE/CED3-Like Protease; Caspase 8; CASP8; MORT1-Associated ced-3 Homolog; CASP-8; Apoptotic Cysteine Protease; FADD-Homologous ICE/ced-3-Like Protease; CAP4; EC 3.4.22.61; Apoptotic Protease Mch-5; ICE-Like Apoptotic Protease 5;

NCIt definition : Caspase-8 (479 aa, 55 kDa) is encoded by the human CASP8 gene. This protein plays a role in proteolysis, angiogenesis and caspase-induction of apoptosis.;

NCIt note : Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.;

Details

Origin ID

C18182;

UMLS CUI

C1144061;

Currated CISMeF NLP mapping
- caspase 8 [MeSH Descriptor]
- caspase 8 [MeSH concept]
OMIM relation
- Caspase 8, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CASP8 protein, human [MeSH concept]
- CASP8 protein, human [MeSH Supplementary Concept]
- caspase 8 [MeSH concept]
- caspase 8 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CASP8 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- D4-GDI Signaling Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- SODD/TNFR1 Signaling Pathway [NCIt concept]
- TNF Receptor Family Signaling Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- TRAIL Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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