DNA Fragmentation Factor Subunit Beta

Preferred Label : DNA Fragmentation Factor Subunit Beta;

NCIt synonyms : Caspase-Activated Deoxyribonuclease; EC 3.-.-.-; DNA Fragmentation Factor 40 kDa Subunit; CPAN; Caspase-Activated Nuclease; DFF-40; Caspase-Activated DNase; CAD; DFFB;

NCIt definition : DNA fragmentation factor subunit beta (338 aa, 39 kDa) is encoded by the human DFFB gene. This protein is involved in the modulation of DNA fragmentation and chromosome condensation during apoptosis.;

NCIt note : DNA fragmentation factor subunit beta (DFFB) is part of DNA fragmentation factor (DFF) along with DNA fragmentation factor subunit alpha (DFFA). DFFA sequesters and inhibits the enzymatic activity of DFFB until caspase-3 cleaves DFFA. (EntrezGene);

Details

Origin ID

C126527;

UMLS CUI

C1504769;

Automatic exact mappings (from CISMeF team)
- Carbamoyl phosphate synthetase/aspartate transcarbamylase/dihydroorotase [OMIM gene]
- Cold agglutinin disease [ORDO Disease]
- Computer aided design [UNESCO concept]
- Coronary atherosclerosis [ICD-11 Category]
- DNA fragmentation factor subunit beta [HGNC gene]
- Dna fragmentation factor, 40-kd, beta subunit [OMIM gene]
- carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [ORDO Gene]
- caspase-activated deoxyribonuclease [MeSH Supplementary Concept]
- caspase-activated deoxyribonuclease [MeSH concept]
- computer-aided design [MeSH Descriptor]
- coronary artery disease [MedlinePlus Topic]
- diagnosis, computer-assisted [EFMI term]
- diagnosis, computer-assisted [MeSH Descriptor]
OMIM relation
- Dna fragmentation factor, 40-kd, beta subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DFFB protein, human [MeSH Supplementary Concept]
- DFFB protein, human [MeSH concept]
gene_encodes_gene_product
- DFFB Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- Apoptotic DNA Fragmentation Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- Granzyme A Mediated Apoptosis Pathway [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Fragmentation [NCIt concept]
- Hydrolysis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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