DR3 and DR4/5 Mediated Apoptosis Pathway

Preferred Label : DR3 and DR4/5 Mediated Apoptosis Pathway;

NCIt synonyms : DR3 and DR4 5 Mediated Apoptosis Pathway;

NCIt related terms : Induction of apoptosis through DR3 and DR4/5 Death Receptors;

Alternative definition : BIOCARTA: Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Apo3L recruits initiator caspase 8 via the adapter protein FADD. Caspase 8 then oligomerizes and is activated via autocatalysis. Activated caspase 8 stimulates apoptosis via two parallel cascades: it directly cleaves and activates caspase-3, and it cleaves Bid (a Bcl-2 family protein). Truncated Bid (tBid) translocates to mitochondria, inducing cytochrome C release, which sequentially activates caspases 9 and 3. DR-3L can deliver pro- or anti-apoptotic signals. DR-3 promotes apoptosis via the adaptor proteins TRADD/FADD and the activation of caspase 8. Alternatively, apoptosis is inhibited via an adaptor protein complex including RIP which activates NF-kB and induces survival genes including IAP. Induction of apoptosis via Apo2L requires caspase activity, but the adaptor requirement is unclear. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_deathPathway;

Details

Origin ID

C39049;

UMLS CUI

C1511707;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Activated Caspase-9 [NCIt concept]
- Apoptosis Regulator Bcl-2 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- BH3-Interacting Domain Death Agonist [NCIt concept]
- Caspase-10 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Growth Arrest-Specific Protein 2 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Lamin-A/C [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Poly [ADP-Ribose] Polymerase 1 [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- Truncated BID [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 10 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 12 [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 25 [NCIt concept]
pathway_has_gene_element
- APAF1 wt Allele [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- BID wt Allele [NCIt concept]
- CASP10 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP6 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- DFFB wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- GAS2 wt Allele [NCIt concept]
- LMNA wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PARP1 wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- TNFRSF10A wt Allele [NCIt concept]
- TNFRSF25 wt Allele [NCIt concept]
- TNFSF10 wt Allele [NCIt concept]
- TNFSF12 wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients