BH3-Interacting Domain Death Agonist

Preferred Label : BH3-Interacting Domain Death Agonist;

NCIt synonyms : BH3 Interacting Domain Death Agonist Protein; BH3 Interacting Domain Death Agonist; BID; p22 BID;

NCIt definition : BH3-interacting domain death agonist (195 aa, 22 kDa) is encoded by the human BID gene. This protein plays a role in the promotion of apoptosis.;

NCIt note : BH3-interacting domain death agonist has 4 isoforms, 3 of them are able to induce apoptosis, through sequestration of anti-apoptotic factors.; Tumor necrosis factor-alpha induces a caspase-mediated cleavage of p22 BH3-interacting domain death agonist into a major p15 and minor p13 and p11 products. Once cleaved, the products become associated with the mitochondrial membrane. (UniProt); BID (BH3 Interacting domain Death agonist) is a death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL2). BID is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. (from RefSeq Summary);

Details

Origin ID

C21199;

UMLS CUI

C1530795;

OMIM relation
- Bh3-interacting domain death agonist [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BH3 interacting domain death agonist protein [MeSH concept]
- BH3 interacting domain death agonist protein [MeSH Descriptor]
- BID protein, human [MeSH concept]
- BID protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BID Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Regulatory Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients