Preferred Label : Alzheimer's Disease Pathway KEGG;

NCIt synonyms : Alzheimers Disease Pathway;

NCIt related terms : Alzheimer's Disease;

Alternative definition : KEGG: Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.;

KEGG ID : hsa05010;

Details


Main resources

You can consult :


https://www.pasteur.fr/fr/centre-medical/fiches-maladies/alzheimer-maladie
2023
France
popular works
Alzheimer's Disease Pathway BioCarta
Alzheimer's Disease
alzheimer disease
alzheimer's disease, nos
Alzheimer's Disease Pathway KEGG

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14/05/2024


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