Alzheimer's Disease Pathway KEGG

Preferred Label : Alzheimer's Disease Pathway KEGG;

NCIt synonyms : Alzheimers Disease Pathway;

NCIt related terms : Alzheimer's Disease;

Alternative definition : KEGG: Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.;

KEGG ID : hsa05010;

Details

Origin ID

C38778;

UMLS CUI

C1521724;

Automatic exact mappings (from CISMeF team)
- ALZHEIMER'S DISEASE [WHO-ART Preferred Term]
- Alzheimer disease [HPO term]
- Alzheimer disease [Radlex concept]
- Alzheimer disease [PASCAL descriptor]
- Alzheimer disease [ICD-11 Category]
- Alzheimer disease, familial, 1 [OMIM Phenotype]
- Alzheimer's disease [DO Concept]
- Alzheimer's disease [MedDRA LLT]
- Alzheimer's disease [LOINC component]
- Alzheimer's disease [ICD-10 category]
- Alzheimer's disease [HPMULTI term]
- Alzheimer's disease [ICD-9 code]
- Alzheimer's disease (disorder) [SNOMED CT concept]
- alzheimer disease [MeSH concept]
- alzheimer disease [MeSH Descriptor]
- alzheimer's disease [MedlinePlus Topic]
- alzheimer's disease [EMDN type]
See also inter- (CISMeF)
- Alzheimer disease [ORDO Disease]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 3 [NCIt concept]
- 26S Proteasome Regulatory Subunit 6A [NCIt concept]
- ATP Synthase Subunit Beta, Mitochondrial [NCIt concept]
- ATP Synthase Subunit Epsilon, Mitochondrial [NCIt concept]
- ATP Synthase Subunit a [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Activating Molecule In BECN1-Regulated Autophagy Protein 1 [NCIt concept]
- Alpha-Synuclein [NCIt concept]
- Amyloid-Beta Precursor Protein [NCIt concept]
- Apolipoprotein E [NCIt concept]
- Apolipoprotein E4 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- BH3-Interacting Domain Death Agonist [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Beta-Secretase 1 [NCIt concept]
- Beta-Secretase 2 [NCIt concept]
- Calcineurin Subunit B Type 1 [NCIt concept]
- Calcineurin Subunit B Type 2 [NCIt concept]
- Calmodulin [NCIt concept]
- Calpain-1 Catalytic Subunit [NCIt concept]
- Calpain-2 Catalytic Subunit [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha [NCIt concept]
- Cytochrome B-245 Heavy Chain [NCIt concept]
- Cytochrome C [NCIt concept]
- Cytochrome C Oxidase Subunit 1 [NCIt concept]
- Cytochrome C Oxidase Subunit 6A2, Mitochondrial [NCIt concept]
- Cytochrome C Oxidase Subunit 6C [NCIt concept]
- Cytochrome C Oxidase Subunit 7A-Related Protein, Mitochondrial [NCIt concept]
- Cytochrome b-c1 Complex Subunit 6, Mitochondrial [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 10 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 17 [NCIt concept]
- Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Gamma-Secretase Subunit PEN-2 [NCIt concept]
- Glutamate Receptor Ionotropic, NMDA 2A [NCIt concept]
- Glutamate Receptor Ionotropic, NMDA 2B [NCIt concept]
- Glutamate Receptor Ionotropic, NMDA 2D [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 2 [NCIt concept]
- Insulin [NCIt concept]
- Insulin-Degrading Enzyme [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Kinesin Heavy Chain Isoform 5A [NCIt concept]
- Kinesin-1 Heavy Chain [NCIt concept]
- Lipoprotein Lipase [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- NADPH Oxidase 1 [NCIt concept]
- NADPH Oxidase 4 [NCIt concept]
- NEDD8-Activating Enzyme E1 Regulatory Subunit [NCIt concept]
- Neprilysin [NCIt concept]
- Nicastrin [NCIt concept]
- Nitric Oxide Synthase, Brain [NCIt concept]
- Presenilin-1 [NCIt concept]
- Presenilin-2 [NCIt concept]
- Prolow-Density Lipoprotein Receptor-Related Protein 1 [NCIt concept]
- Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase ULK2 [NCIt concept]
- Serine/Threonine-Protein Kinase/Endoribonuclease IRE1 [NCIt concept]
- Succinate Dehydrogenase Cytochrome b560 Subunit, Mitochondrial [NCIt concept]
- Succinate Dehydrogenase [Ubiquinone] Cytochrome B Small Subunit, Mitochondrial [NCIt concept]
- Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit, Mitochondrial [NCIt concept]
- Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial [NCIt concept]
- Tubulin Beta-4A Chain [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1S [NCIt concept]
pathway_has_gene_element
- ADAM10 wt Allele [NCIt concept]
- ADAM17 wt Allele [NCIt concept]
- AMBRA1 wt Allele [NCIt concept]
- APAF1 wt Allele [NCIt concept]
- APOE wt Allele [NCIt concept]
- APOE*2 Allele [NCIt concept]
- APOE*4 Allele [NCIt concept]
- APP wt Allele [NCIt concept]
- ATF6 wt Allele [NCIt concept]
- ATP2A2 wt Allele [NCIt concept]
- ATP5F1B wt Allele [NCIt concept]
- ATP5F1E wt Allele [NCIt concept]
- BACE1 wt Allele [NCIt concept]
- BACE2 wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BID wt Allele [NCIt concept]
- CACNA1C wt Allele [NCIt concept]
- CACNA1D wt Allele [NCIt concept]
- CACNA1S wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CAPN1 wt Allele [NCIt concept]
- CAPN2 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- COX6A2 wt Allele [NCIt concept]
- COX6C wt Allele [NCIt concept]
- COX7A2L wt Allele [NCIt concept]
- CYBB wt Allele [NCIt concept]
- CYCS wt Allele [NCIt concept]
- EIF2AK3 wt Allele [NCIt concept]
- ERN1 wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- GRIN2A wt Allele [NCIt concept]
- GRIN2B wt Allele [NCIt concept]
- GRIN2D wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- IDE wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- INS wt Allele [NCIt concept]
- ITPR1 wt Allele [NCIt concept]
- ITPR2 wt Allele [NCIt concept]
- KIF5A wt Allele [NCIt concept]
- KIF5B wt Allele [NCIt concept]
- LPL wt Allele [NCIt concept]
- LRP1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MME wt Allele [NCIt concept]
- MT-ATP6 wt Allele [NCIt concept]
- MT-CO1 wt Allele [NCIt concept]
- NAE1 wt Allele [NCIt concept]
- NCSTN wt Allele [NCIt concept]
- NOS1 wt Allele [NCIt concept]
- NOX1 wt Allele [NCIt concept]
- NOX4 wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PSEN1 wt Allele [NCIt concept]
- PSEN2 wt Allele [NCIt concept]
- PSENEN wt Allele [NCIt concept]
- PSMC3 wt Allele [NCIt concept]
- PSMD3 wt Allele [NCIt concept]
- SDHA wt Allele [NCIt concept]
- SDHB wt Allele [NCIt concept]
- SDHC wt Allele [NCIt concept]
- SDHD wt Allele [NCIt concept]
- SNCA wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TUBB4A wt Allele [NCIt concept]
- ULK2 wt Allele [NCIt concept]
- UQCRH wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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