Nitric Oxide Synthase, Brain

Preferred Label : Nitric Oxide Synthase, Brain;

NCIt synonyms : NC-NOS; Constitutive NOS; NOS Type I; Nitric Oxide Synthetase-1; NOS1; Brain Nitric Oxide Synthase; Neuronal NOS; Neuronal Nitric Oxide Synthase; bNOS; EC 1.14.13.39; Peptidyl-Cysteine S-Nitrosylase NOS1; Nitric Oxide Synthase 1; N-NOS; nNOS;

NCIt definition : Nitric oxide synthase, brain (1434 aa, 161 kDa) is encoded by the human NOS1 gene. This protein plays a role in both amino acid metabolism and nitric oxide production.;

NCIt note : Nitric oxide synthase, brain binds FAD and FMN cofactors, contains a PDZ/DHR and a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes nitric oxide messenger from L-arginine.;

Details

Origin ID

C38563;

UMLS CUI

C0907533;

OMIM relation
- Nitric oxide synthase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- NOS1 protein, human [MeSH concept]
- NOS1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- NOS1 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Tilarginine [NCIt concept]
gene_product_has_structural_domain_or_motif
- PDZ Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Arginine and Proline Metabolism Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Nitric Oxide Signaling Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- Sumoylation in Modulation of CtBP-Dependent Gene Response Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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