Preferred Label : Sumoylation in Modulation of CtBP-Dependent Gene Response Pathway;
NCIt related terms : SUMOylation as a mechanism to modulate CtBP-dependent gene responses;
Alternative definition : BIOCARTA: Covalent attachment of one eukaryotic protein to another is a prominent
posttranslational modification and Ubiquitin is the most familiar of the protein modifiers.
Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the
most intriguing of them is SUMO (small ubiquitin-like modifier, 12kDa) also known
as Sentrin. SUMO family has been described in vertebrates: SUMO-1 and the closest
homologs SUMO-2 and SUMO-3. SUMO have been shown to bind and regulate mammalian SP-RINGs
(such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, CtBP,
Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR),
GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1,
HPV/BPV-E1. In the case of the transcription co-repressor CtBP, which can be recruited
to the target promoter via interaction with a conserved PxDLS motif in the interacting
repressor, CtBP SUMOylation profoundly affected its subcellular localization. SUMOylation
occurred at a single Lys residue, Lys428, of CtBP1. Mutating Lys428 into Arg (K428R)
shifted CtBP1 from the nucleus to the cytoplasm, while it had little effect on its
interaction with the PxDLS motif. The K428R mutation also abolished the ability of
CtBP1 to repress the E-cadherin promoter activity. Consistent with the known inhibitory
effect of nNOS on the nuclear accumulation of CtBP1, PDZ domain of nNOS inhibits the
SUMOylation of CtBP1. The current data indicates that SUMOylation can regulate CtBP1-dependent
transcriptional repression. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_ctbp1Pathway;
Origin ID : C39039;
UMLS CUI : C1515054;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
