Long-Term Depression Pathway

Preferred Label : Long-Term Depression Pathway;

NCIt related terms : Long-term depression;

Alternative definition : KEGG: Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization.;

KEGG ID : hsa04730;

Details

Origin ID

C91463;

UMLS CUI

C2984275;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- 85 kDa Calcium-Independent Phospholipase A2 [NCIt concept]
- Corticoliberin [NCIt concept]
- Corticotropin-Releasing Factor Receptor 1 [NCIt concept]
- Cytosolic Phospholipase A2 [NCIt concept]
- Cytosolic Phospholipase A2 Beta [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glutamate Receptor 1 [NCIt concept]
- Glutamate Receptor 2 [NCIt concept]
- Glutamate Receptor 3 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(o) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(z) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-12 [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-13 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Alpha-1 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Alpha-2 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Beta-1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 2 [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Metabotropic Glutamate Receptor 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Nitric Oxide Synthase, Brain [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Alpha Isoform [NCIt concept]
- Tyrosine-Protein Kinase Lyn [NCIt concept]
- Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1A [NCIt concept]
- cGMP-Dependent Protein Kinase 1 [NCIt concept]
- cGMP-Dependent Protein Kinase 2 [NCIt concept]
pathway_has_gene_element
- ARAF wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CACNA1A wt Allele [NCIt concept]
- CRH wt Allele [NCIt concept]
- CRHR1 wt Allele [NCIt concept]
- GNA12 wt Allele [NCIt concept]
- GNA13 wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAI2 wt Allele [NCIt concept]
- GNAI3 wt Allele [NCIt concept]
- GNAO1 wt Allele [NCIt concept]
- GNAZ wt Allele [NCIt concept]
- GRIA1 wt Allele [NCIt concept]
- GRIA2 wt Allele [NCIt concept]
- GRIA3 wt Allele [NCIt concept]
- GRM1 wt Allele [NCIt concept]
- GUCY1A1 wt Allele [NCIt concept]
- GUCY1A2 wt Allele [NCIt concept]
- GUCY1B1 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- ITPR1 wt Allele [NCIt concept]
- ITPR2 wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- LYN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- NOS1 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PLA2G4A wt Allele [NCIt concept]
- PLA2G4B wt Allele [NCIt concept]
- PLA2G6 wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PPP2CA wt Allele [NCIt concept]
- PPP2CB wt Allele [NCIt concept]
- PPP2R1A wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PRKG1 wt Allele [NCIt concept]
- PRKG2 wt Allele [NCIt concept]
- RYR1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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