GUCY1A2 wt Allele

Preferred Label : GUCY1A2 wt Allele;

NCIt synonyms : Guanylate Cyclase 1, Soluble, Alpha 2 wt Allele; GUCSA2; GC-SA2; GUC1A2; Guanylate Cyclase 1, Soluble, Alpha-2 Gene;

NCIt definition : Human GUCY1A2 wild-type allele is located within 11q21-q22 and is approximately 331 kb in length. This allele, which encodes guanylate cyclase soluble subunit alpha-2 protein, is involved in cyclic GMP biosynthesis and nitric oxide binding.;

NCIt note : The GUCY1A2 gene produces two RNA transcript variants via alternative splicing which, in turn, encode two distinct isoforms of guanylate cyclase soluble subunit alpha-2 protein. One of these isoforms, alpha-2-I, is a negative regulator of guanylyl cyclase activity.;

GenBank Accession Number : NM_000855;

Details

Origin ID

C52036;

UMLS CUI

C1708159;

OMIM relation
- Guanylate cyclase 1, soluble, alpha-2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_has_physical_location
- 11: 106394381-106063120 [NCIt concept]
gene_in_chromosomal_location
- 11q21-q22 [NCIt concept]
gene_is_element_in_pathway
- Gap Junction Assembly Pathway [NCIt concept]
- Ion Channels in Vascular Endothelium Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_plays_role_in_process
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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