Salivary Secretion Pathway

Preferred Label : Salivary Secretion Pathway;

NCIt related terms : Salivary secretion;

Alternative definition : KEGG: Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2 , which leads to fluid secretion; that is, water and ion transport. Ca2 also induces amylase secretion, but the amount is smaller than that induced by cAMP.;

KEGG ID : hsa04970;

Details

Origin ID

C91810;

UMLS CUI

C2984575;

Automatic exact mappings (from CISMeF team)
- Salivary secretion, function (observable entity) [SNOMED CT concept]
- salivation [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 [NCIt concept]
- Adenylate Cyclase Type 9 [NCIt concept]
- Alpha-1A Adrenergic Receptor [NCIt concept]
- Alpha-1B Adrenergic Receptor [NCIt concept]
- Beta-1 Adrenergic Receptor [NCIt concept]
- Beta-2 Adrenergic Receptor [NCIt concept]
- Beta-3 Adrenergic Receptor [NCIt concept]
- Calcium-Activated Potassium Channel Subunit Alpha-1 [NCIt concept]
- Calmodulin [NCIt concept]
- Cystatin-D [NCIt concept]
- Cystatin-S [NCIt concept]
- Cystatin-SA [NCIt concept]
- Cystatin-SN [NCIt concept]
- Deleted in Malignant Brain Tumors 1 Protein [NCIt concept]
- Guanylate Cyclase Soluble Subunit Alpha-1 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Alpha-2 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Beta-1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 2 [NCIt concept]
- Lysozyme C [NCIt concept]
- Mucin-5B [NCIt concept]
- Muscarinic Acetylcholine Receptor M3 [NCIt concept]
- Nitric Oxide Synthase, Brain [NCIt concept]
- Plasma Membrane Calcium-Transporting ATPase 3 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Sodium/Hydrogen Exchanger 1 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Alpha-1 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Alpha-3 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Beta-3 [NCIt concept]
- Solute Carrier Family 12 Member 2 [NCIt concept]
- Transient Receptor Potential Cation Channel Subfamily V Member 6 [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
- cGMP-Dependent Protein Kinase 1 [NCIt concept]
- cGMP-Dependent Protein Kinase 2 [NCIt concept]
pathway_has_gene_element
- ADCY9 wt Allele [NCIt concept]
- ADRA1A wt Allele [NCIt concept]
- ADRA1B wt Allele [NCIt concept]
- ADRB1 wt Allele [NCIt concept]
- ADRB2 wt Allele [NCIt concept]
- ADRB3 wt Allele [NCIt concept]
- ATP1A1 wt Allele [NCIt concept]
- ATP1A3 wt Allele [NCIt concept]
- ATP1B3 wt Allele [NCIt concept]
- ATP2B3 wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CD38 wt Allele [NCIt concept]
- CHRM3 wt Allele [NCIt concept]
- CST1 wt Allele [NCIt concept]
- CST2 wt Allele [NCIt concept]
- CST4 wt Allele [NCIt concept]
- CST5 wt Allele [NCIt concept]
- DMBT1 wt Allele [NCIt concept]
- GUCY1A1 wt Allele [NCIt concept]
- GUCY1A2 wt Allele [NCIt concept]
- GUCY1B1 wt Allele [NCIt concept]
- ITPR1 wt Allele [NCIt concept]
- ITPR2 wt Allele [NCIt concept]
- KCNMA1 wt Allele [NCIt concept]
- LYZ wt Allele [NCIt concept]
- MUC5B wt Allele [NCIt concept]
- NOS1 wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PRKG1 wt Allele [NCIt concept]
- PRKG2 wt Allele [NCIt concept]
- SLC12A2 wt Allele [NCIt concept]
- SLC9A1 wt Allele [NCIt concept]
- TRPV6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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