Guanylate Cyclase Soluble Subunit Alpha-2

Preferred Label : Guanylate Cyclase Soluble Subunit Alpha-2;

NCIt synonyms : GUCY1A2; GCS-Alpha-2; Soluble Guanylate Cyclase 1A2; Soluble Guanylate Cyclase Alpha-2 Chain; Soluble Guanylate Cyclase 1 Alpha 2; NOGC, Alpha-2 Subunit; Nitric Oxide-Sensitive Guanylyl Cyclase, Alpha-2 Subunit; Soluble Guanylate Cyclase-1-Alpha-2; Guanylyl Cyclase, Nitric Oxide-Sensitive, Alpha-2 Subunit;

NCIt definition : Guanylate cyclase soluble subunit alpha-2 (732 aa, 82 kDa) is encoded by the human GUCY1A2 gene. This protein is involved in cyclic GMP synthesis.;

NCIt note : The active soluble guanylate cyclase enzyme is a heterodimer composed of one guanylate cyclase soluble subunit alpha, alpha-1 (GUCY1A1) or alpha-2, (GUCY1A2) and one guanylate cyclase soluble subunit beta, beta-1 (GUCY1B1) or beta-2 (GUCY1B2).; Protein_Plays_Role_In_Biological_Process: cGMP Synthesis;

Details

Origin ID

C38422;

UMLS CUI

C1519417;

OMIM relation
- Guanylate cyclase 1, soluble, alpha-2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- GUCY1A2 protein, human [MeSH Supplementary Concept]
- GUCY1A2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GUCY1A2 Gene [NCIt concept]
- Lyase Gene [NCIt concept]
gene_product_has_biochemical_function
- Soluble Guanylate Cyclase [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Gap Junction Assembly Pathway [NCIt concept]
- Ion Channels in Vascular Endothelium Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_is_physical_part_of
- Soluble Guanylate Cyclase [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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