Soluble Guanylate Cyclase

Preferred Label : Soluble Guanylate Cyclase;

NCIt synonyms : Guanylate Cyclase, Soluble; sGC; GUCY; Soluble Guanylyl Cyclase; EC 4.6.1.2;

NCIt definition : Human Soluble Guanylate Cyclases (Adenylyl Cyclase 4/Guanylyl Cyclase Family) are heterodimeric (alpha/beta) nitric oxide-activated cytoplasmic enzymes that catalyze conversion of GTP to cGMP second messenger. The main receptors for nitric oxide in the cardiovascular system and for nitrovasodilator drugs, alpha/beta interaction is required for guanylyl cyclase activity. (NCI);

NCIt note : Protein_Plays_Role_In_Biological_Process: cGMP Synthesis;

Details

Origin ID

C20141;

UMLS CUI

C4082850;

Biochemical function of gene products
- Guanylate Cyclase Soluble Subunit Alpha-1 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Alpha-2 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Beta-1 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Beta-2 [NCIt concept]
Currated CISMeF NLP mapping
- soluble guanylyl cyclase [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_product_has_biochemical_function
- Guanylate Cyclase [NCIt concept]
- Lyase [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
has_gene_product_element
- Guanylate Cyclase Soluble Subunit Alpha-2 [NCIt concept]
is_target
- Methylene Blue Oral Rinse [NCIt concept]

Keyword's position in hierarchy(ies) :

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