Guanylate Cyclase Soluble Subunit Beta-2

Preferred Label : Guanylate Cyclase Soluble Subunit Beta-2;

NCIt synonyms : GUCY1B2; Soluble Guanylate Cyclase 1B2; Soluble Guanylate Cyclase Beta-2 Chain; GCS-Beta-2; Soluble Guanylate Cyclase 1 Beta 2; Soluble Guanylate Cyclase-1-Beta-2;

NCIt definition : Guanylate cyclase soluble subunit beta-2 (617 aa, 70 kDa) is encoded by the human GUCY1B2 gene. This protein is involved in guanine nucleotide triphosphate conversion to cyclic guanine nucleotide monophosphate.;

NCIt note : Guanylate cyclase soluble subunit beta-2 evidence is only at the transcript level, according to UniProt. HGNC and EntrezGene consider GUCY1B2 a pseudogene.; Protein_Plays_Role_In_Biological_Process: cGMP Synthesis; The active soluble guanylate cyclase enzyme is a heterodimer composed of one guanylate cyclase soluble subunit alpha, alpha-1 (GUCY1A1) or alpha-2, (GUCY1A2) and one guanylate cyclase soluble subunit beta, beta-1 (GUCY1B1) or beta-2 (GUCY1B2).;

Details

Origin ID

C38428;

UMLS CUI

C1519419;

OMIM relation
- Guanylate cyclase 1, soluble, beta-2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GUCY1B2 Gene [NCIt concept]
- Lyase Gene [NCIt concept]
gene_product_has_biochemical_function
- Soluble Guanylate Cyclase [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ion Channels in Vascular Endothelium Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]

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