Guanylate Cyclase

Preferred Label : Guanylate Cyclase;

NCIt synonyms : EC 4.6.1.2;

NCIt definition : Guanylate cyclase (GC) is an enzyme that converts GTP to the second messenger cyclic GMP (cGMP). There are two forms: plasma membrane GCs that are receptors for hormones, and intracellular soluble GCs that are activated by the gaseous second messenger nitric oxide (NO). EC 4.6.1.2;

Details

Origin ID

C16653;

UMLS CUI

C0018358;

Automatic exact mappings (from CISMeF team)
- natriuretic peptide receptor 1 [HGNC gene]
Biochemical function of gene products
- Atrial Natriuretic Peptide Receptor 1 [NCIt concept]
- Atrial Natriuretic Peptide Receptor 2 [NCIt concept]
- Heat-Stable Enterotoxin Receptor [NCIt concept]
- Soluble Guanylate Cyclase [NCIt concept]
Currated CISMeF NLP mapping
- guanylate cyclase [MeSH Descriptor]
- guanylate cyclase [MeSH concept]
- guanylate cyclase [SNOMED Notion]
False automatic mappings
- Guanylate cyclase (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Guanylate cyclase (substance) [SNOMED CT concept]
- guanylate cyclase [MeSH concept]
- guanylate cyclase [SNOMED Notion]
- guanylate cyclase [MeSH Descriptor]
gene_product_has_biochemical_function
- Lyase [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
is_target
- Autologous GCC-targeting CAR T Cells GCC19CART [NCIt concept]

Keyword's position in hierarchy(ies) :

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