Heat-Stable Enterotoxin Receptor

Preferred Label : Heat-Stable Enterotoxin Receptor;

NCIt synonyms : StAR; GUCY2C; Guanylyl Cyclase C; Guanylate Cyclase 2C; hSTAR; Guanylyl Cyclase 2C; STA Receptor; Intestinal Guanylate Cyclase; EC 4.6.1.2; Heat Stable Enterotoxin Receptor; GC-C; GCC;

NCIt definition : Heat-stable enterotoxin receptor (1073 aa, 123 kDa) is encoded by the human GUCY2C gene. This protein is involved in ligand-stimulated guanylate cyclase activity.;

NCIt note : Ligands for heat-stable enterotoxin receptor include E.coli heat-stable enterotoxin, guanylin and uroguanylin. (UniProt);

Details

Origin ID

C123877;

UMLS CUI

C1451001;

Automatic exact mappings (from CISMeF team)
- Actin-binding rho-activating protein [OMIM gene]
- Goblet cell carcinoma [ORDO Disease]
- Guanylate cyclase 2c [OMIM gene]
- Receptors, Enterotoxin [MeSH Descriptor]
- Stars [UNESCO concept]
- Steroidogenic acute regulatory protein [OMIM gene]
- Toe syndactyly, telecanthus, and anogenital and renal malformations [OMIM Phenotype]
- guanylate cyclase 2C [ORDO Gene]
- guanylate cyclase 2C [HGNC gene]
- steroidogenic acute regulatory protein [ORDO Gene]
OMIM relation
- Guanylate cyclase 2c [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- GUCY2C protein, human [MeSH Supplementary Concept]
- GUCY2C protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GUCY2C Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Lyase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_biochemical_function
- Guanylate Cyclase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Purine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine [NCIt concept]
- Anti-CD3/Anti-GUCY2C Bispecific Antibody PF-07062119 [NCIt concept]
- Anti-GCC Antibody-Drug Conjugate TAK-164 [NCIt concept]
- Anti-GUCY2C CAR-T Cells [NCIt concept]
- Gallium Ga 68-labeled MLN6907 [NCIt concept]
- Indusatumab Vedotin [NCIt concept]
- Zirconium Zr 89-TAK-164 [NCIt concept]

Keyword's position in hierarchy(ies) :

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