NCIt definition : An antibody-drug conjugate (ADC) containing a monoclonal antibody directed against
guanylyl cyclase C (GCC or GUCY2C) conjugated to monomethylauristatin E (MMAE), an
auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic
activity. The monoclonal antibody moiety of indusatumab vedotin selectively binds
to GCC, a transmembrane receptor normally found on intestinal cells and dopamine neurons
in the brain, but is also overexpressed on the surface of gastrointestinal cancers.
Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits
its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis in GCC-expressing
tumor cells.;
Automatic exact mappings (from CISMeF team)