NCIt definition : A bispecific antibody against human CD3, a T-cell surface antigen, and human guanylate
cyclase 2C (GUCY2C; GCC; guanylyl cyclase C; heat-stable enterotoxin receptor; hSTAR),
with potential antineoplastic activity. Upon administration, anti-CD3/anti-GUCY2C
bispecific antibody PF-07062119 targets and binds to both CD3 on T-cells and GUCY2C
expressed on certain tumor cells. This results in the cross-linking of T-cells and
tumor cells, and induces a cytotoxic T-lymphocyte (CTL) response against GUCY2C-expressing
tumor cells. GUCY2C, a transmembrane receptor expressed on intestinal epithelial cells,
is overexpressed on certain tumors of the gastrointestinal (GI) tract.;
Semantic type(s)