NCIt synonyms : T-Cell Surface Glycoprotein CD3; T3 Complex;
NCIt related terms : CD3;
NCIt definition : A protein complex comprised of one T-cell surface glycoprotein CD3 delta chain (CD3D),
one T-cell surface glycoprotein CD3 gamma chain (CD3G) and two T-cell surface glycoprotein
CD3 epsilon chains (CD3E). CD3D, CD3G and CD3E are transmembrane proteins with one
extracellular immunoglobulin domain and one intracellular ITAM domain. The CD3 complex
is a T-cell co-receptor that noncovalently associates with either the disulfide bound
heterodimeric alpha/beta T-cell receptor (TCR) or gamma/delta TCR and two copies of
the accessory protein, T-cell surface glycoprotein CD3 zeta chain (CD247), which is
a transmembrane protein with three ITAM domains. The TCR moiety of the TCR-CD3 complex
binds to MHC and processed antigens on antigen presenting cells, which triggers phosphorylation
of and cellular propagation of the signal by CD247 and the CD3 complex.;