NCIt definition : A humanized, bispecific monoclonal antibody (BsAb) targeting CD3, a T-cell surface
antigen, and CD38, a human cell surface glycoprotein and tumor-associated antigen
(TAA), with potential antineoplastic activity. Upon intravenous administration, anti-CD3/CD38
bispecific monoclonal antibody AMG 424 binds to both CD3 on T-cells and CD38 expressed
on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte
(CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane
glycoprotein, is present on various immune cells and hematologic malignancies; its
expression has been correlated with poor prognosis.;
Semantic type(s)