" /> Cevostamab - CISMeF





Preferred Label : Cevostamab;

NCIt synonyms : Anti-FCRH5 x Anti-CD3 Bi-specific T-cell Engager BFCR4350A; Anti-FCRH5/CD3 TDB BFCR4350A; FCRH5/CD3 TDB Antibody BFCR4350A; Recombinant Anti-FCRH5 x Anti-CD3 Bi-specific T-cell Engager BFCR4350A; FCRH5/CD3 T Cell Dependent Bispecific Antibody BFCR4350A; Anti-FCRH5/CD3 BiTE Antibody BFCR4350A;

NCIt definition : A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) Fc receptor-like protein 5 (FCRH5; CD307; FCRL5; IRTA2; BXMAS1) and one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of cevostamab, the bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and FCRH5 found on FCRH5-expressing tumor cells. This activates and crosslinks CTLs with FCRH5-expressing tumor cells, which results in the CTL-mediated cell death of FCRH5-expressing tumor cells. FCRH5, an immune receptor translocation-associated protein/Fc receptor homolog (IRTA/FCRH) family member and a B-cell lineage marker, is overexpressed on myeloma cells.;

UNII : P86BHN01VE;

CAS number : 2249888-53-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2249888-53-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RO7187797; BFCR4350A;

NCI Metathesaurus CUI : CL526909;

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12/05/2024


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