Preferred Label : CD3 Complex;
MeSH definition : Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that
are non-covalently associated with one another and with the T-cell receptor (RECEPTORS,
ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta
chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces
the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains
(subunits) are separate from and not related to the gamma/delta chains of the T-cell
receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).;
MeSH synonym : antigen, t3; cd3 antigens; t3 antigens; antigens, t3; cd3 antigen; antigen, cd3; t3 complex; t3 antigen; Antigens, CD3;
MeSH annotation : T-lymphocyte differentiation antigens;
Is substance : O;
Origin ID : D017252;
UMLS CUI : C0108779;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that
are non-covalently associated with one another and with the T-cell receptor (RECEPTORS,
ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta
chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces
the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains
(subunits) are separate from and not related to the gamma/delta chains of the T-cell
receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
