Preferred Label : Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine;
NCIt synonyms : Ad5-hGCC-PADRE Vaccine;
NCIt definition : A replication-defective, recombinant adenoviral serotype 5 (Ad5) encoding human guanylyl
cyclase C (hGCC) and the synthetic Pan DR epitope (PADRE), with potential antineoplastic
and immunomodulating activities. Upon intramuscular administration, the Ad5-hGCC-PADRE
vaccine expresses hGCC, which may induce both humoral and cellular immune responses
against tumor cells expressing the hGCC antigen. This results in the immune-mediated
inhibition of tumor cell proliferation, and leads to tumor death. The hGCC protein
is normally restricted to intestinal epithelial cells but is overexpressed by metastatic
colorectal tumors. PADRE is a helper T-lymphocyte epitope that is able to augment
the magnitude and duration of the cytotoxic T-lymphocyte (CTL) response.;
NCI Metathesaurus CUI : CL454294;
Origin ID : C112005;
UMLS CUI : C3831604;
Semantic type(s)
- concept_is_in_subset
- has_target
