Preferred Label : Anti-GUCY2C CAR-T Cells;
NCIt synonyms : Anti-guanylate Cyclase 2C CAR T Cells; GUCY2C-targeting CAR T-cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting human guanylate cyclase 2C (GUCY2C; GCC; guanylyl
cyclase C; heat-stable enterotoxin receptor; hSTAR), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-GUCY2C CAR-T cells target
and bind to GUCY2C-expressing tumor cells, thereby inducing selective toxicity in
GUCY2C-expressing tumor cells. GUCY2C, a transmembrane receptor expressed on intestinal
epithelial cells, is overexpressed on certain tumors of the gastrointestinal (GI)
tract.;
NCI Metathesaurus CUI : CL1661926;
Origin ID : C179261;
UMLS CUI : C5555562;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
