Autologous GCC-targeting CAR T-cells LCAR-G08

Preferred Label : Autologous GCC-targeting CAR T-cells LCAR-G08;

NCIt synonyms : LCAR-G08 Cells; Autologous GCC-targeting CAR-T Cells LCAR-G08; Autologous GUCY2C-targeting CAR T-cells LCAR-G08; Autologous Anti-GCC-CAR T-cells LCAR-G08; LCAR-G08T;

NCIt definition : A preparation of autologous T-lymphocytes that are genetically engineered, using a lentiviral vector, to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T-cells LCAR-G08 are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types.;

Molecule name : LCAR G08; LCAR-G08;

NCI Metathesaurus CUI : CL1927037;

Details

Origin ID

C204807;

UMLS CUI

C5908064;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Heat-Stable Enterotoxin Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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