Preferred Label : Zirconium Zr 89-TAK-164;
NCIt synonyms : 89Zr-TAK-164;
NCIt definition : A radioimmunoconjugate composed of TAK-164, an antibody-drug conjugate (ADC) comprised
of a full-length, human immunoglobulin G1 (IgG1) monoclonal antibody (mAb) directed
against the extracellular domain of guanylyl cyclase C (GCC; GUCY2C) conjugated to
the DNA alkylator DGN549 (IGN-P1), and linked to the radioisotope zirconium Zr 89
(Zr89), with potential use in imaging of GCC-expressing tumor cells upon positron
emission tomography (PET). Upon administration of zirconium Zr 89-TAK-164, the TAK-164
moiety targets and binds to GCC. After binding, Zr89 facilitates the visualization
and detection of GCC-expressing tumor cells using PET. This assesses GCC-expression
and may predict or evaluate the tumor's response to TAK-164.;
NCI Metathesaurus CUI : CL976998;
Origin ID : C163762;
UMLS CUI : C5235661;
Semantic type(s)
- concept_is_in_subset
- has_target
